OpenClinica CE XML Injection in CRF Data Import <=3.13
CVE-2025-12921 Published on November 9, 2025

OpenClinica Community Edition CRF Data Import ImportCRFData xml injection
A vulnerability has been found in OpenClinica Community Edition up to 3.12.2/3.13. Affected by this issue is some unknown functionality of the file /ImportCRFData?action=confirm of the component CRF Data Import. Such manipulation of the argument xml_file leads to xml injection. It is possible to launch the attack remotely. The exploit has been disclosed to the public and may be used. The vendor was contacted early about this disclosure but did not respond in any way.

NVD

Timeline

Advisory disclosed

VulDB entry created

VulDB entry last update

Weakness Types

What is an aka Blind XPath Injection Vulnerability?

The software does not properly neutralize special elements that are used in XML, allowing attackers to modify the syntax, content, or commands of the XML before it is processed by an end system. Within XML, special elements could include reserved words or characters such as "<", ">", """, and "&", which could then be used to add new data or modify XML syntax.

CVE-2025-12921 has been classified to as an aka Blind XPath Injection vulnerability or weakness.

What is an Injection Vulnerability?

The software constructs all or part of a command, data structure, or record using externally-influenced input from an upstream component, but it does not neutralize or incorrectly neutralizes special elements that could modify how it is parsed or interpreted when it is sent to a downstream component. Software has certain assumptions about what constitutes data and control respectively. It is the lack of verification of these assumptions for user-controlled input that leads to injection problems. Injection problems encompass a wide variety of issues -- all mitigated in very different ways and usually attempted in order to alter the control flow of the process. For this reason, the most effective way to discuss these weaknesses is to note the distinct features which classify them as injection weaknesses. The most important issue to note is that all injection problems share one thing in common -- i.e., they allow for the injection of control plane data into the user-controlled data plane. This means that the execution of the process may be altered by sending code in through legitimate data channels, using no other mechanism. While buffer overflows, and many other flaws, involve the use of some further issue to gain execution, injection problems need only for the data to be parsed. The most classic instantiations of this category of weakness are SQL injection and format string vulnerabilities.

CVE-2025-12921 has been classified to as an Injection vulnerability or weakness.


Affected Versions

OpenClinica Community Edition:

Exploit Probability

EPSS
0.04%
Percentile
12.70%

EPSS (Exploit Prediction Scoring System) scores estimate the probability that a vulnerability will be exploited in the wild within the next 30 days. The percentile shows you how this score compares to all other vulnerabilities.